Rosso di Montepulciano is a simpler version of Vino Nobile, intended for earlier consumption, lighter foods, and everyday drinking. Poliziano has dedicated some of its vineyards specifically for the Rosso, working to produce grapes that are best suited for producing a young, fruity wine, full bodied but not overly tannic. It is made from 80% Prugnolo Gentile (Sangiovese) grapes, supported by Merlot. The Rosso is the foundation wine of the Poliziano lineup.

Vino Nobile di Montepulciano is the principal wine of Poliziano. Revered by nobility through the centuries, Vino Nobile was often hailed as "the wine of kings." Today, Vino Noble is still considered to be special, thanks to the Prugnolo Gentile clone of Sangiovese that is grown in the Montepulciano area. Poliziano uses 85% Prugnolo Gentile in their blend, along with two traditional Tuscan varieties, Colorino and Canaiolo, and a bit of Merlot. The complementary varieties add color, depth, and complexity to the elegance of the Sangiovese.

The Vino Nobile di Montepulciano from the Asinone vineyard is the flagship wine of Poliziano. After years of continual experimentation, this particular vineyard was identified as the one with the best quality potential. Asinone is well ventilated and has poor soil that gives the Sangiovese just the right vigor. Though Vino Nobile requires only 70% Sangiovese in the blend, this wine uses 95% to showcase the excellence of the Prugnolo Gentile (Sangiovese) from this vineyard.

n 1986 Poliziano purchased the Caggiole vineyard which is comprised of 14 hectares and divided into three parcels.  The ability of the vineyard to produce a very high-quality wine was apparent from the onset and in 1988 the first vintage of Nobile Caggiole was produced.  In 1995 the winery stopped production of Caggiole to focus on Vino Nobile di Montepulciano "Asinone". After many years of devoting their time and attention to the Caggiole vineyard by experimenting with new clones, increasing plant density with non-vigorous rootstock perfect for the soil, and moving in an organic direction and eliminating pesticides and chemical fertilizers from the soil, the winery decided to reintroduce Vino Nobile di Montepulciano DOCG Il Caggiole with the 2015 vintage, a 100% Sangiovese of great elegance.  

Looking for new areas to expand wine production in different directions, Poliziano became interested in Cortona, in the Val di Chiana about 15 miles (25 km) northeast of Montepulciano. The Cortona DOC, established in 1999, promotes various nontraditional grape varieties, and in 2006, Poliziano began a new enological project there. Seeing great potential for Merlot cultivated in the Pliocene clays of Cortona, the winery began producing In Violas, a 100% Merlot wine. “In Violas” is the name of an elegaic poem by Angelo Poliziano, a renowned Montepulciano-born Renaissance writer and scholar.

Le Stanze del Poliziano is a very modern red wine, made from mostly Cabernet Sauvignon with a small addition of Merlot. It is the winery’s sole Super Tuscan, a high-quality wine made outside the rules of its denomination. Though grown in Montepulciano, Le Stanze steps away from the Vino Nobile and Chianti format with a wine intended for international tastes using classic Bordeaux grape varieties. The name Le Stanze del Poliziano refers to the poetry (stanzas) of Angelo Poliziano, a renowned Montepulciano-born Renaissance writer and scholar.